Ultrasound-guided percutaneous irreversible electroporation of hepatic and abdominal tumors not eligible for surgery or thermal ablation: a western report on safety and efficacy.

Giorgio A1, Amendola F2, Calvanese A3, Ingenito E3, Santoro B4, Gatti P5, Ciracì E5, Matteucci P6, Giorgio V7.

Author information:
1. Interventional Ultrasound Unit, Tortorella Clinical Institute, Salerno, Italy. Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo..
2. Interventional Ultrasound Unit, Tortorella Clinical Institute, Salerno, Italy.
3. Oncology Unit, Tortorella Clinical Institute, Salerno, Italy.
4. Interventional Ultrasound Unit, Athena Clinical Institute, Caserta, Italy.
5. Internal Medicine Unit, Ostuni Hospital, Ostuni (BR), Italy.
6. Radiation Therapy Unit, Campus Biomedico University, Rome, Italy.
7. Pediatric Gastroenterology Unit, Fondazione Policlinico A.Gemelli IRCCS, Department of Woman and Child Health and Public Health; Roma- Italy, Rome, Italy.



To report our first results on sixteen patients affected by liver and abdominal malignant tumors, unfit for surgery or thermal ablation, treated with US-guided percutaneous irreversible electroporation (IRE).


From June 2014 to December 2016, all patients meeting the inclusion criteria (malignant hepatic or abdominal tumors not eligible for resection or thermal ablation) and not meeting the exclusion criteria (heart arrhythmia, pro-hemorrhagic hematological alterations, tumor size > 8 cm, presence of a biliary metallic stent) referred to our institutions were prospectively enrolled to undergo percutaneous US- guided irreversible electroporation (IRE). Sixteen patients (age range 59-68 years, mean 63; 7 females) with 18 tumors (diameter range 1.3-7.5 cm) fulfilled the inclusion criteria and were included in the study. Data concerning efficacy (tested by a 1-week CEUS and a 4-week enhanced CT and/or enhanced MRI) and safety were recorded during a 18-month follow up.


All patients completed a 35-50-min procedure without complications. One patient with 6 cm Klatskin tumor also underwent a second session for 1 month. A 1-week CEUS and a 4-week e-CT and/or e-MRI arterial phase contrast enhancement analysis showed an overall reduction of arterial flow with confirmation of unenhanced lesions for seven nodules. After 1-18 months of follow up, no major

complications were recorded and no tumor-related death occurred. The lesions of two patients disappeared 3 and 6 months after their treatment, respectively.


IRE is a promising ablation modality in the treatment of malignant hepatic and abdominal tumors unsuitable for resection or thermal ablation.
PMID: 30843171

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